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Harry Connick Jr. - Dr. Dennis Slamon, Tammy Blanchard - Nicole Wilson, Amanda Bynes - Jamie McGrath, Jennifer Coolidge - Tish, Angie Harmon - Lilly Tartikoff, John Benjamin Hickey - Blake Rogers, Regina King - Ellie Jackson, Swoosie Kurtz - Elizabeth, Paula Cale - Donna Slamon (as Paula Cale Lisbe) , Amy Madigan - Fran Visco, Bernadette Peters - Barbara Bradfield, Trudie Styler - Tina, Bruce McKinnon - Dean Bradfield, Jackson Hurst - Josh, Tom Nowicki - Carl Reinhardt