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Uma Thurman - Jenny Johnson / G-Girl, Luke Wilson - Matt Saunders, Anna Faris - Hannah Lewis, Rainn Wilson - Vaughn Haige, Eddie Izzard - Professor Bedlam / Barry, Stelio Savante - Leo, Mike Iorio - Lenny, Mark Consuelos - Steve Velard, Wanda Sykes - Carla Dunkirk, Margaret Anne Florence - Shapely Bartender, Catherine Reitman - TV News Reporter, Tara Thompson - Young Jenny (as Tara L. Thompson) , Kevin Townley - Young Barry, Eva Veronika - Elderly Lady, Lawrence Feeney - Scary Dude