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Keira Knightley - Sabina Spielrein, Viggo Mortensen - Sigmund Freud, Michael Fassbender - Carl Jung, Vincent Cassel - Otto Gross, Sarah Gadon - Emma Jung, André Hennicke - Prof. Eugen Bleuler (as André M. Hennicke) , Arndt Schwering-Sohnrey - Sándor Ferenczi, Mignon Remé - Jung's Secretary, Mareike Carrière - Food Nurse, Franziska Arndt - Bath Nurse, Wladimir Matuchin - Nikolai Spielrein, André Dietz - Medical Policeman, Anna Thalbach - Bathtub Patient, Sarah Marecek - Orchard Nurse, Bjorn Geske - Orderly (as Björn Geske)