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Hugh Grant - Dr. Guy Luthan, Gene Hackman - Dr. Lawrence Myrick, Sarah Jessica Parker - Jodie Trammel, David Morse - FBI Agent Frank Hare, Bill Nunn - Det. Bob Burke, John Toles-Bey - Bobby, Paul Guilfoyle - Dr. Jeffrey Manko, Debra Monk - Dr. Judith Gruszynski, Shaun Austin-Olsen - Claude Minkins, André De Shields - Teddy Dolson, J.K. Simmons - Dr. Mingus, Peter Appel - Det. Stone, Diana Zimmer - Helen, Nancy Beatty - Ruth Myrick, Gerry Becker - Dr. Gene Spitelli