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Jenifer Lewis - Jackie Washington, Tim Curry - Edward Whatsett St. John, T.V. Blake - Antandra Washington (Jackie's Daughter), Tangie Ambrose - Shaniqua Summers Wells (Jackie's Daughter), Whoopi Goldberg - Nurse Ethyl Washington Rue Owens (Jackie's Sister), Robert Bailey Jr. - Wilson Wells (Jackie's Grandson), Loren Freeman - Kim (Jackie's Costume Designer), Tom Arnold - Marvin Pritz (Jackie's Former Manager), Patti Austin - Patti Austin (Gospel Singer at Peaches' Funeral), Loretta Devine - Snookie Tate (Jackie's Childhood Friend), Julie Hagerty - Pammy Dunbar (Host), David Hyde Pierce - Perry (The Deaf Rehearsal Pianist), Kathy Najimy - Lola Molina (Jackie's Stalker), Isabel Sanford - Miss Krumes (Jackie's Play Mama), JoBeth Williams - Jo Face (Jackie's Vocal Coach)