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Jennifer Aniston - Justine Last, Deborah Rush - Gwen Jackson, Mike White - Corny, John Carroll Lynch - Jack Field, Your Store Manager, Jake Gyllenhaal - Holden Worther, Zooey Deschanel - Cheryl, John C. Reilly - Phil Last, Tim Blake Nelson - Bubba, Jacquie Barnbrook - Heavy Set Woman, Annie O'Donnell - Haggard Woman, John Doe - Mr. Worther, Roxanne Hart - Mrs. Worther, Jon Shere - Lester (as Jonathan Shere) , Alice Amter - Big Haired Woman, Jean Rhodes - Old Woman